Guardiola’s latest injury setback for a key player puts his plans in jeopardy ahead of the Manchester derby, offering a boost to Manchester United.

As the 197th Manchester Derby looms on Sunday, September 14, 2025, at the Etihad Stadium, Manchester City manager Pep Guardiola is facing a mounting injury crisis that could tilt the scales in favor of rivals Manchester United. The latest blow came during the international break, with star forward Omar Marmoush suffering a knee injury while on duty with Egypt, leaving Guardiola anxiously awaiting updates on the player’s fitness. With a host of key players already sidelined, this setback adds to City’s challenges as they aim to reverse a dismal start to the 2024/25 Premier League season, while United, under Ruben Amorim, look to capitalize on their rivals’ misfortune in this blockbuster clash.

Marmoush, the 26-year-old Egyptian who joined City for £59 million from Eintracht Frankfurt in January, was forced off just nine minutes into a World Cup qualifier against Burkina Faso after a heavy tackle from Mohamed Zougrana. The forward, visibly in pain as he clutched his knee, was later spotted on crutches in Cairo, with initial scans indicating a bruised knee ligament. City confirmed the grim news on their official website: “Initial results on a scan performed in Egypt indicate he will not be available for the Manchester derby on Sunday, and he will now return to Manchester for more assessment and to begin his rehabilitation.” This injury is a bitter pill for Guardiola, who has relied on Marmoush’s unpredictability and flair, evidenced by an assist in City’s opening matches, to bolster an attack that has struggled for consistency.

The timing couldn’t be worse for City, who are languishing in 13th place after a torrid start to the season. A 4-0 thrashing of Wolverhampton Wanderers on the opening weekend raised hopes, but back-to-back defeats—a 2-0 loss to Tottenham and a 2-1 collapse against Brighton—have exposed vulnerabilities. Marmoush’s absence joins an already alarming injury list, with key defenders John Stones, Josko Gvardiol, and Manuel Akanji doubtful, alongside midfielders Mateo Kovacic and Kevin De Bruyne, and forwards Phil Foden and Rayan Cherki. Stones, sent home early from England duty with a minor muscle issue, is a particular concern, with England manager Thomas Tuchel noting, “He came with minor issues and didn’t progress as we thought and hoped he would.” The mounting absences heap pressure on Erling Haaland, who is in scintillating form after scoring five goals in Norway’s 11-1 rout of Moldova, to carry City’s attack single-handedly.

Guardiola, whose side have never lost two of their opening three league games in his tenure until this season, remains defiant despite the setbacks. “We have to find a way,” he said in a recent press conference, emphasizing his team’s resilience. “Injuries are part of football, and the players who step up will show what we’re about.” Yet, the derby’s stakes are sky-high, with local bragging rights and crucial Premier League points on the line. City’s depleted squad faces a United side that, while not without their own injury concerns, appears better positioned. United’s Matheus Cunha and Mason Mount are doubtful after picking up knocks in a 3-2 win over Burnley, and Lisandro Martinez remains sidelined with an ACL injury, but Amorim’s squad has avoided the scale of City’s woes, giving them a potential edge.

The Etihad clash, set to kick off at 3:00 p.m. UK time, will be broadcast live on BBC One and streamed on BBC iPlayer in the UK, with global coverage on platforms like Sky Sports and DAZN, depending on the region. For US fans, the match may be available via streaming services like Peacock, which has covered select Premier League fixtures. The atmosphere is expected to be electric, with United’s recent resurgence under Amorim—highlighted by a gritty win over Burnley—adding fuel to one of football’s fiercest rivalries.

City’s injury crisis has sparked debate about their depth and preparation, with up to 11 players potentially missing the derby. Alongside Marmoush, Stones, and Gvardiol, names like Jack Grealish, Kyle Walker, Bernardo Silva, and Matheus Nunes are also in doubt, testing Guardiola’s tactical ingenuity. United, meanwhile, are buoyed by the early return of Casemiro to training and the potential availability of Martinez, offering hope of a competitive lineup. Social media buzz suggests City fans are bracing for a tough battle, with one post noting Haaland’s “six goals in eight derbies” as a glimmer of hope amid the gloom.

As the countdown to Sunday continues, Guardiola faces a critical moment to rally his squad. A victory could kickstart City’s season and silence doubters, but United, smelling blood, will look to exploit their rivals’ fragility. For fans, the Manchester Derby promises drama, passion, and the chance to see whether City’s depleted roster can rise to the occasion or if United will seize a rare opportunity to dominate their neighbors.

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